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  Codeine binds to opioid receptors in the brain and spinal cord, reducing the transmission of pain signals and providing relief. For cough suppression, it dampens the cough reflex in the brainstem. Codein is metabolized by the CYP2D6 enzyme—a crucial step for its effectiveness. However, genetic variations cause some individuals (especially children and ultra-rapid metabolizers) to be more susceptible to adverse effects, leading to regulatory restrictions in certain populations.

   

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